Bipolar spindles which might be shaped within the absence of Aurora A perform often exhibit chromosome alignment and segregation defects, together with chromosome congression defects at metaphase, lagging chromosomes at anaphase, and telophase bridges. In step with the chromosome segregation defects, cells handled with MLN8054 build aneuploidy that
Hepatic biotransformation of MLN8054 was studied in vitro making use of human liver S9 fractions (Knowledge on file, Millennium). Glucuronidation with the carboxylate moiety of MLN8054 to an acyl glucuronide was the predominant mechanism of biotransformation, Hydroxylation on the azepine moiety of MLN8054 was the most important stage 1 biotransform
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